Vaccinology and Methods in Vaccine Research

Vaccinology and Methods in Vaccine Research (Developments in Immunology) 1st Edition:

Chapter 1. Immunology and the concept of vaccination
Abstract
Manipulation of the immune system by vaccination
Overview of immunity and the immune system
Prophylactic and therapeutic vaccines
References
Chapter 2. Vaccine types and reverse vaccinology
Abstract
Introduction
Fundamentals of vaccine immunology
Classes of vaccines
Immunoinformatics
References
Chapter 3. Dendritic cells as vaccine targets
Abstract
Introduction to dendritic cells
Origin and types of dendritic cells
Location of dendritic cells
Receptors of dendritic cells
References
Further reading
Chapter 4. Vaccine development: from the laboratory to the field
Abstract
Introduction
Antigen selection for new vaccines
Genetic studies
Basic protein studies
Other methods of in vitro evaluation of immunogenicity
Conclusion
References
Further reading
Chapter 5. Harnessing the power of CD8+ T-cells: identification and validation of peptides bound to major histocompatibility complex class I by immunopeptidomics
Abstract
CD8+ T cells and major histocompatibility complex class I antigen presentation
Proteasome cleavage mechanisms
Intracellular trafficking of peptides
Peptide binding affinity to major histocompatibility complex class I
Tools for discovering immunogenic peptides
Immunopeptidomics
Vaccine design based on immunopeptidomics
Methods for the validation of immunogenic peptides
Conclusions
Acknowledgments
References
Chapter 6. Virus-like particle vaccines
Abstract
Introduction
Immune response to virus-like particles
Production of virus-like particles
Expression systems
Manufacturing: upstream process
Manufacturing: purification of virus-like particles (downstream process)
Major contaminants and removal strategies
Analytical tools for virus-like particles
Conclusion
References
Chapter 7. Approaches to cancer vaccination
Abstract
Introduction
Types of cancer vaccines
Novel trends in cancer vaccine development
Cancer vaccine delivery systems
Summary
References
Chapter 8. Vaccines against SARS-CoV-2
Abstract
The COVID-19 pandemic
The spike protein of the SARS-CoV-2 virus
COVID-19 vaccine development
Nucleic acid–based vaccines
Viral vector vaccines
Antigen-presenting cell-based vaccines
Whole organism-based vaccines
Future vaccine requirements and challenges
References
Chapter 9. Adjuvants, immunomodulators, and adaptogens
Abstract
Introduction
Aluminum-based adjuvants
Emulsion-based adjuvants
Saponins
Immune stimulating complexes
TLR agonists
Nanoparticles
Liposomes
Exosomes
GSK adjuvant systems
Cholera toxin
Freund’s adjuvant
?-GalCer
Adjuvant properties of the microbiome
Plant-derived adaptogens
References
Chapter 10. GMP manufacture and quality control
Abstract
Introduction
Regulation
GMP manufacture
Vaccine purification
In process controls and final release testing
References
Chapter 11. Testing vaccines: essential steps in clinical trial design
Abstract
Introduction
Vaccine development pathway
Introduction to good clinical practice
Consent
Good clinical practice compliant documentation
Clinical trial roles and responsibilities
Ensuring quality
Safety
Adverse events
Other trial considerations
Final word
References
Index

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