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Immunology 9th Edition
Immunology Ninth Edition:
Covering all the basic and clinical concepts you need to know for your coursework and USMLEs, Immunology, 9th Edition, offers a well-illustrated, carefully structured approach to this complex and fast-changing field. Carefully edited and authored by experts in both teaching and research, it provides cutting-edge, consistent coverage that links the laboratory and clinical practice. A user-friendly, color-coded format, including key concept boxes, explanatory diagrams, and nearly 200 photos to help you visually grasp and retain challenging concepts.
- Explains the building blocks of the immune system – cells, organs, and major receptor molecules – as well as initiation and actions of the immune response, especially in a clinical context.
- Includes extensive updates to clinical information, including recent clinical approaches in cancer immunology, transplantation, autoimmunity, hypersensitivity, and more.
- Features a reorganized format that presents immunology in the order in which is typically taught and learned, better integrating basic and clinical immunology.
- Covers new topics such as innate lymphoid cells, antibody-based therapies and antibody engineering, innate immunity and its components, the genetics of immunologically-based diseases and personalized medicine, and immunotherapeutic agents for the treatment of cancer.
- Provides Critical Thinking boxes, chapter-opening summaries, and case-based and USMLE-style questions that provide effective review and quick practice for exams – plus more learning opportunities online, including USMLE-style questions and clinical cases.
- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. It also features full color 3-D animations to deliver a dynamic visual overview of immunological concepts.
Includes extensive updates to clinical information, including recent clinical approaches in cancer immunology, transplantation, autoimmunity, hypersensitivity, and more.
Covers new topics such as innate lymphoid cells, antibody-based therapies and antibody engineering, innate immunity and its components, the genetics of immunologically-based diseases and personalized medicine, and immunotherapeutic agents for the treatment of cancer.
Additional ISBNs:
∗ eText ISBN: 0702078468, 978-0702078460, 9780702078460
- See additional information on the Amazon.
More Details
Preface to the 9th edition
Contributors
Section 1: The Immune System and Innate Immunity
1: Introduction to the Immune System
Cells and soluble mediators of the immune system
Inflammation
Immune responses to pathogens
Antigen recognition
Antigen presentation
Antigen elimination
Vaccination
Immunopathology
Normal but inconvenient immune reactions
2: Cells, Tissues and Organs of the Immune System
Cells of the immune system
Myeloid cells
Eosinophils, basophils and mast cells in inflammation
Antigen-presenting cells
Lymphocytes
Innate lymphoid cells (ILC)
Lymphocyte development
B cells
Lymphoid organs
Lymphocyte recirculation
3: Mechanisms of Innate Immunity
Innate immune responses
Inflammation – a response to tissue damage
Leukocyte migration to lymphoid tissues
Mediators of inflammation
Pathogen-associated molecular patterns
4: Complement
Complement and inflammation
Complement activation pathways
Complement protection systems
The membrane attack pathway
Membrane receptors for complement products
Complement functions
Complement deficiencies
Complement polymorphisms and disease
Complement therapeutics
5: Mononuclear Phagocytes in Immune Defence
Macrophages: the ‘big eaters’
Phagocytosis and endocytosis
Functions of phagocytic cells
Section 2: Adaptive Immune Responses
6: T-Cell Receptors and Major Histocompatibility Complex Molecules
MHC genes
T-cell receptors
Generation of T-cell receptor diversity
The T-cell receptor complex
Major histocompatibility complex haplotype and disease susceptibility
7: Antigen Presentation
Antigen-presenting cells
Antigen processing
Major histocompatibility complex class i pathway
Major histocompatibility complex class ii pathway
CD1 Pathway
CO-Stimulation
T-Cell signalling
8: Cell-Mediated Cytotoxicity
Cytotoxic lymphocytes
NK-Cell Development
NK-Cell receptors
Cytotoxicity
Non-lymphoid cytotoxic cells
9: B-Cell Development and the Antibody Response
B-Cell development
B-Cell activation
B-Cell differentiation and the antibody response
Somatic hypermutation and class-switch recombination
10: Antibodies
Antibody structural and serological variations
Antigen–antibody interactions
Antibody effector functions
Fc receptors
Antibody engineering
11: Immunological Tolerance
Generation of autoreactive antigen receptors during lymphocyte development
T-Cell tolerance
Regulatory T cells
T-Cell anergy
B-Cell tolerance
12: Regulation of the Immune Response
T-Cell and B-Cell Regulation by Antigen
Regulation by the antigen-presenting cell
T-Cell Regulation of the Immune Response
Immune Regulation by Selective Cell Migration
Regulatory T Cells
Regulation of the Immune Response by Immunoglobulins
Apoptosis in the Immune System
Metabolic Regulation of the Immune Response
T-Cell Activation Involves a Switch from Oxphos to Glycolysis
Neuroendocrine Regulation of Immune Responses
13: Immune Responses in Tissues
Tissue-Specific Immune Responses
Immune Reactions in the CNS
Immune Reactions in the Eye
Immune Responses in the Gut and Lung
Immune Reactions in the Liver
Immune Reactions in the Skin
Conclusions
Section 3: Defence Against Infectious Agents
14: Immunity to Viruses
Innate Immune Defences Against Viruses
Interferons Enhance The Antiviral Activity of Macrophages And Nk Cells
Adaptive Immune Responses To Viral Infection
Virus Strategies To Evade Host Immune Responses
Pathological Consequences Of Immune Responses Induced By Viral Infections
15: Immunity to Bacteria and Fungi
Innate recognition of bacterial components
Lymphocyte-independent effector systems
Antibody-dependent antibacterial defences
Bacterial killing by phagocytes
Direct antibacterial actions of t cells
Immunopathological reactions induced by bacteria
Fungal infections
16: Immunity to Protozoa and Worms
Parasite Infections
Immune Defences Against Parasites
Innate Immune Responses
Adaptive Immune Responses to Parasites
Immune Effector Cells
Parasite Escape Mechanisms
Immunopathological Consequences of Parasite Infections
Vaccines Against Human Parasites
17: Vaccination
Vaccination
Antigen preparations used in vaccines
Adjuvants enhance antibody production
Vaccine administration
Vaccine efficacy and safety
Vaccines in general use have variable success rates
Passive immunization
Immunization against non-infectious conditions
Future vaccines
Section 4: Immunodeficiency
18: Primary Immunodeficiencies
B-Lymphocyte Deficiencies
T-Lymphocyte Deficiencies
Disorders of Immune Regulation
Immunodeficiency Syndromes
Genetic Defects of Phagocytes
Immunodeficiencies With Selective Susceptibility To Infections
Genetic Deficiencies of Complement Proteins
19: AIDS, Secondary Immunodeficiency and Immunosuppression
Overview
Nutrient Deficiencies
Immunodeficiency Secondary to Drug Therapies
Other Causes of Secondary Immunodeficiencies
Section 5: Immune Responses Against Tissues
20: Autoimmunity and Autoimmune Disease
Autoimmunity and Autoimmune Disease
Genetic Factors in Autoimmunity
Autoimmunity and Autoimmune Disease
Induction of Autoimmunity
Autoimmune Processes and Pathology
Autoantibodies for Diagnosis, Prognosis and Monitoring
Treatment of Autoimmune Diseases
21: Transplantation and Rejection
Transplantation in clinical practice
Genetic barriers to transplantation
Graft rejection
Immune effector mechanisms in graft rejection
Preventing Rejection
Induction of donor-specific tolerance
22: Immunity to Cancers
Tumour Immunity in the Primary Host
Characterization of Tumour Antigens
Anti-Tumour Immune Responses
Immunotherapy for Human Cancer
Section 6: Hypersensitivity
23: Immediate Hypersensitivity (Type I)
Classification of hypersensitivity reactions
Historical perspective on immediate hypersensitivity
Characteristics of type I reactions
Characteristics of allergens
Mediators released by mast cells and basophils
Genetic associations with asthma
Skin tests for diagnosis and to guide treatment
Allergens contribute to asthma
Treatments for type I hypersensitivity
24: Hypersensitivity (Type II)
Mechanisms of tissue damage
TYPE II Reactions against blood cells and platelets
Type II Hypersensitivity Reactions in Tissues
Autoantibodies and Autoimmune Disease
25: Hypersensitivity (Type III)
Immune complex diseases
Immune complexes and inflammation
Experimental models of immune complex diseases
Immune complexes clearance by the mononuclear phagocyte system
Immune complex deposition in tissues
Diagnosis of immune complex disease
26: Hypersensitivity (Type IV)
Delayed-type Hypersensitivity Reactions
Type IVa Reactions Require Macrophages as Effector Cells
Type IVb Reactions Involve Eosinophils as Effector Cells
Type IVc Reactions Involve CD8+ T Cells as Effector Cells
Type IVd Reactions Involve Neutrophils as Effector Cells
Critical thinking: Explanations
1 Specificity and Memory in Vaccination
2 Development of the Immune System
3 The Role of Adhesion Molecules in T-Cell Migration
4 Complement Deficiency
5 The Role of Macrophages in Toxic Shock Syndrome
The role of macrophages in Th1 and Th2 responses
6 MHC Restriction
7 Antigen Processing and Presentation
8 Mechanisms of Cytotoxicity
9 Development of the Antibody Response
10 The Specificity of Antibodies
11 Immunological Tolerance
12 Regulation of the Immune Response
13 Immune Reactions in the Gut
14 Virus–Immune System Interactions
15 Immunoendocrine Interactions in the Response to Infection
16 Immunity to Protozoa and Helminths
17 Vaccination
18 Hyper-IgM immunodeficiency
19 Secondary Immunodeficiency
20 Autoimmunity and Autoimmune Disease
21 Transplantation
22 Immunity to Cancers
23 Severe Anaphylactic Shock
24 Blood Groups and Haemolytic Disease of the Newborn
25 Type III Serum Sickness After Factor IX Administration
26 A Hypersensitivity Type IV Reaction
Glossary
Index
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