Principles of Neural Science, Sixth Edition
Principles of Neural Science, Sixth Edition 6th Edition:
The gold standard of neuroscience texts―updated with hundreds of brand-new images and fully revised content in every chapter
Doody’s Core Titles for 2021!
For more than 40 years, Principles of Neural Science has helped readers understand the link between the human brain and behavior. As the renowned text has shown, all behavior is an expression of neural activity and the future of both clinical neurology and psychiatry is dependent on the progress of neural science. Fully updated, this sixth edition of the landmark reference reflects the latest research, clinical perspectives, and advances in the field. It offers an unparalleled perspective on the the current state and future of neural science.
This new edition features:
- Unmatched coverage of how the nerves, brain, and mind function
- NEW chapters on:
– The Computational Bases of Neural Circuits that Mediate Behavior
– Brain-Machine Interfaces
– Decision-Making and Consciousness
- NEW section on the neuroscientific principles underlying the disorders of the nervous system
- Expanded coverage of the different forms of human memory
- Highly detailed chapters on stroke, Parkinson’s disease, and multiple sclerosis
- 2,200 images, including 300 new color illustrations, diagrams, radiology studies, and PET scans
Principles of Neural Science, Sixth Edition benefits from a cohesive organization, beginning with an insightful overview of the interrelationships between the brain, nervous system, genes, and behavior.
The text is divided into nine sections:
Part I: Overall Perspective provides an overview of the broad themes of neural science, including the basic anatomical organization of the nervous system and the genetic bases of nervous system function and behavior.
Part II: Cell and Molecular Biology of Cells of the Nervous System examines the basic properties of nerve cells, including the generation and conduction of propagated signaling.
Part III: Synaptic Transmission focuses on the electrophysiological and molecular mechanism of synaptic transmission with chapters on neuronal excitability, neurotransmitters, and transmitter release.
Part IV: Perception discusses the various aspects of sensory perception, including how information from the primary organs of sensation is transmitted to and processed by the central nervous system.
Part V: Movement considers the neural mechanisms underlying movement and examines a new treatment that addresses how the basal ganglia regulate the selection of motor actions and instantiate reinforcement learning.
Part VI: The Biology of Emotion, Motivation and Homeostasis examines the neural mechanisms by which subcortical areas mediate homeostatic control mechanisms, emotions, and motivation.
Part VII: Development and the Emergence of Behavior looks at the nervous system from early embryonic differentiation to the formation and elimination of synapses.
Part VIII: Learning, Memory, Language and Cognition expands on the previous section, examining the cellular mechanisms of implicit and explicit memory storage, as well as decision-making and consciousness.
Part IX: explores the neural mechanisms underlying diseases and disorders of the nervous system, including autism spectrum disorder, epilepsy, schizophrenia, and anxiety.
Table of Contents
Part I: Overall Perspective
Chapter 1: The Brain and Behavior
Chapter 2: Genes and Behavior
Chapter 3: Nerve Cells, Neural Circuitry, and Behavior
Chapter 4: The Neuroanatomical Bases by Which Neural Circuits Mediate Behavior
Chapter 5: The Computational Bases of Neural Circuits That Mediate Behavior
Chapter 6: Imaging and Behavior
Part II: Cell and Molecular Biology of Cells of the Nervous System
Chapter 7: The Cells of the Nervous System
Chapter 8: Ion Channels
Chapter 9: Membrane Potential and the Passive Electrical Properties of the Neuron
Chapter 10: Propagated Signaling: The Action Potential
Part III: Synaptic Transmission
Chapter 11: Overview of Synaptic Transmission
Chapter 12: Directly Gated Transmission: The Nerve-Muscle Synapse
Chapter 13: Synaptic Integration in the Central Nervous System
Chapter 14: Modulation of Synaptic Transmission and Neuronal Excitability: Second Messengers
Chapter 15: Transmitter Release
Chapter 16: Neurotransmitters
Part IV: Perception
Chapter 17: Sensory Coding
Chapter 18: Receptors of the Somatosensory System
Chapter 19: Touch
Chapter 20: Pain
Chapter 21: The Constructive Nature of Visual Processing
Chapter 22: Low-Level Visual Processing: The Retina
Chapter 23: Intermediate-Level Visual Processing and Visual Primitives
Chapter 24: High-Level Visual Processing: From Vision to Cognition
Chapter 25: Visual Processing for Attention and Action
Chapter 26: Auditory Processing by the Cochlea
Chapter 27: The Vestibular System
Chapter 28: Auditory Processing by the Central Nervous System
Chapter 29: Smell and Taste: The Chemical Senses
Part V: Movement
Chapter 30: Principles of Sensorimotor Control
Chapter 31: The Motor Unit and Muscle Action
Chapter 32: Sensory-Motor Integration in the Spinal Cord
Chapter 33: Locomotion
Chapter 34: Voluntary Movement: Motor Cortices
Chapter 35: The Control of Gaze
Chapter 36: Posture
Chapter 37: The Cerebellum
Chapter 38: The Basal Ganglia
Chapter 39: Brain-Machine Interfaces
Part VI: The Biology of Emotion, Motivation, and Homeostasis
Chapter 40: The Brain Stem
Chapter 41: The Hypothalamus: Autonomic, Hormonal, and Behavioral Control of Survival
Chapter 42: Emotion
Chapter 43: Motivation, Reward, and Addictive States
Chapter 44: Sleep and Wakefulness
Part VII: Development and the Emergence of Behavior
Chapter 45: Patterning the Nervous System
Chapter 46: Differentiation and Survival of Nerve Cells
Chapter 47: The Growth and Guidance of Axons
Chapter 48: Formation and Elimination of Synapses
Chapter 49: Experience and the Refinement of Synaptic Connections
Chapter 50: Repairing the Damaged Brain
Chapter 51: Sexual Differentiation of the Nervous System
Part VIII: Learning, Memory, Language and Cognition
Chapter 52: Learning and Memory
Chapter 53: Cellular Mechanisms of Implicit Memory Storage and the Biological Basis of Individuality
Chapter 54: The Hippocampus and the Neural Basis of Explicit Memory Storage
Chapter 55: Language
Chapter 56: Decision-Making and Consciousness
Part IX: Diseases of the Nervous System
Chapter 57: Diseases of the Peripheral Nerve and Motor Unit
Chapter 58: Seizures and Epilepsy
Chapter 59: Disorders of Conscious and Unconscious Mental Processes
Chapter 60: Disorders of Thought and Volition in Schizophrenia
Chapter 61: Disorders of Mood and Anxiety
Chapter 62: Disorders Affecting Social Cognition: Autism Spectrum Disorder
Chapter 63: Genetic Mechanisms in Neurodegenerative Diseases of the Nervous System
Chapter 64: The Aging Brain
Eric R. Kandel, MD, is University Professor and Kavli Professor of Brain Science, and Codirector of Columbia University’s Zuckerman Institute; and Senior Investigator at the Howard Hughes Medical Institute. He is the recipient of the 2000 Nobel Prize in Physiology or Medicine for his research on the physiological basis of memory storage in neurons.
Steven A. Siegelbaum, PhD, is Gerald D. Fischbach, M.D. Professor of Neuroscience; Professor of Pharmacology; Chair of the Department of Neuroscience; and Principle Investigator at Columbia University’s Zuckerman Institute.
Sarah H. Mack (deceased) was a gifted artist with a deep understanding and appreciation of neuroscience. Co-editor of Principles of Neural Science, Sixth Edition, she directed the art program for the book for more than thirty years.
John Koester, PhD, is Professor Emeritus of Clinical Neuroscience and Psychiatry at Columbia University.