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Cellular and Molecular Immunology 10th Edition
Cellular and Molecular Immunology Tenth Edition:
Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area. It’s an ideal resource for medical, graduate, and undergraduate students, as well as a trusted reference for physicians and scientists.
- Highlights the implications of immunologic science for the management of human disease, emphasizing clinical relevance throughout.
- Employs a highly accessible writing style that makes difficult concepts easier to understand, and provides clear implications of immunologic science to the management of human disease and clinical practice.
- Features updates from cover to cover, including new information on intracellular sensors of innate immunity, therapeutic use of monoclonal antibodies, regulation of migration events during T cell-B cell interactions, regulatory and transcriptional events in germinal center formation, immunology of infectious diseases including coronaviruses, human immunodeficiency disorders, and immunology of HIV.
- Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program, including many new and extensively revised illustrations.
- Helps readers grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions.
- Includes summary boxes that assist with rapid review and mastery of key material.
- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access multiple-choice questions that correspond to each chapter, plus all of the text, figures, and references from the book on a variety of devices.
Additional ISBNs:
∗ eText ISBN: 0323757502, 978-0323757508, 9780323757508
- See additional information on the Amazon.
More Details
Preface
Online Resources for Instructors and Students
Chapter 1. Properties and Overview of Immune Responses
Innate and Adaptive Immunity
Innate Immunity
Adaptive Immunity
Summary
Chapter 2. Cells and Tissues of the Immune System
Cells of the Immune System
Anatomy and Functions of Lymphoid Tissues
Summary
Chapter 3. Leukocyte Circulation and Migration Into Tissues
Overview of Leukocyte Migration
Adhesion Molecules on Leukocytes and Endothelial Cells Involved in Leukocyte Recruitment
Chemokines and Chemokine Receptors
Leukocyte-Endothelial Interactions and Leukocyte Recruitment into Tissues
Migration of Neutrophils and Monocytes to Sites of Infection or Tissue Injury
Migration and Recirculation of T Lymphocytes
Migration of B Lymphocytes
Summary
Chapter 4. Innate Immunity
Overview of Innate Immunity
Recognition of Microbes and Damaged Tissue by the Innate Immune System
Cellular Pattern Recognition Receptors
Cellular Components of the Innate Immune System
Soluble Effector Molecules of Innate Immunity
The Inflammatory Response
The Antiviral Response
Stimulation of Adaptive Immunity
Mechanisms that Limit Innate Immune Responses
Summary
Chapter 5. Antibodies and Antigens
Antibody Structure
Synthesis, Assembly, and Expression of Immunoglobulin Molecules
Antibody Binding of Antigens
Structure-Function Relationships in Antibody Molecules
Summary
Chapter 6. Antigen Presentation to T Lymphocytes and the Function of Major Histocompatibility Complex Molecules
Properties of Antigens Recognized by T Lymphocytes
Antigen Capture and the Functions of Antigen-Presenting Cells
The Major Histocompatibility Complex
Processing of Protein Antigens
Presentation of Nonprotein Antigens to T Cells
Summary
Chapter 7. Immune Receptors and Signal Transduction
Overview of Signal Transduction
The Immune Receptor Family
The T Cell Receptor Complex and T Cell Signaling
The B Lymphocyte Antigen Receptor Complex
The Attenuation of Immune Receptor Signaling
Cytokine Receptors and Signaling
Summary
Chapter 8. Lymphocyte Development and Antigen Receptor Gene Rearrangement
Overview of Lymphocyte Development
Rearrangement of Antigen Receptor Genes in B and T Lymphocytes
B Lymphocyte Development
T Lymphocyte Development
Summary
Chapter 9. Activation of T Lymphocytes
Overview of T Lymphocyte Activation
Signals for T Lymphocyte Activation
Functional Responses of T Lymphocytes
Decline of T Cell Responses
Summary
Chapter 10. Differentiation and Functions of CD4+ Effector T Cells
Overview of CD4+ T Cell–Mediated Immune Responses
Subsets of CD4+ Effector T Cells
The Th1 Subset
The Th2 Subset
The Th17 Subset
Functions of Other HELPER T Cell Subsets
Summary
Chapter 11. Differentiation and Functions of CD8+ Effector T Cells
Differentiation of CD8+ T Cells Into Cytotoxic T Lymphocytes
Effector Functions of CD8+ Cytotoxic T Lymphocytes
Cytokine Production by CD8+ Effector T Cells
Roles of CD8+ Cytotoxic T Lymphocytes in Host Defense
Summary
Chapter 12. B Cell Activation and Antibody Production
Overview of Humoral Immune Responses
Antigen Recognition and Antigen-Induced B Cell Activation
Helper T Cell–Dependent Antibody Responses to Protein Antigens
Antibody Responses to T-Independent Antigens
Antibody Feedback: Regulation of Humoral Immune Responses By Fc Receptors
Summary
Chapter 13. Effector Mechanisms of Humoral Immunity
Overview of Humoral Immunity
Neutralization of Microbes and Microbial Toxins
Antibody-Mediated Opsonization and Phagocytosis
The Complement System
Summary
Chapter 14. Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
General Features of Immunity at Epithelial Barriers
Immunity in the Gastrointestinal System
Immunity in Other Mucosal Tissues
The Cutaneous Immune System
Immune-Privileged Tissues
Immunity in the Mammalian Fetus and Newborn
Summary
Chapter 15. Immunologic Tolerance and Autoimmunity
Overview of Immunologic Tolerance
T Lymphocyte Tolerance
B Lymphocyte Tolerance
Tolerance to Commensal Microbes and Other Foreign Antigens
Mechanisms of Autoimmunity
Summary
Chapter 16. Immunity to Microbes
Overview of Immune Responses to Microbes
Immunity to Extracellular Bacteria
Immunity to Intracellular Bacteria
Immunity to Fungi
Immunity to Viruses
Immunity to Parasites
Strategies for Vaccine Development
Summary
Chapter 17. Transplantation Immunology
General Principles of Transplantation Immunology
Immune Responses to Allografts
Patterns and Mechanisms of Allograft Rejection
Prevention and Treatment of Allograft Rejection
Xenogeneic Transplantation
Blood Transfusion and the Abo and Rh Blood Group Antigens
Hematopoietic Stem Cell (HSC) Transplantation
Summary
Chapter 18. Tumor Immunology
Overview of Tumor Immunity
Tumor Antigens
Immune Responses To Tumors
Evasion of Immune Responses by Tumors
Immunotherapy For Tumors
Summary
Chapter 19. Hypersensitivity Disorders
Causes of Hypersensitivity Diseases
Mechanisms and Classification of Hypersensitivity Reactions
Diseases Caused by Antibodies and Antigen-Antibody Complexes
Diseases Caused by T Lymphocytes
Therapeutic Approaches for Immunologic Diseases
Selected Immunologic Diseases: Pathogenesis and Therapeutic Strategies
Summary
Chapter 20. Allergy
Overview of IgE-Dependent Allergic Reactions
Production of IgE
Cells Involved in Allergic Reactions
Reactions Dependent on IgE and Mast Cells
Genetic Susceptibility to Allergic Disease
Allergic Diseases in Humans: Pathogenesis and Therapy
The Protective Roles of Immune Reactions Mediated by IgE and Mast Cells
Summary
Chapter 21. Primary and Acquired Immunodeficiencies
Overview of Immunodeficiency Diseases
Primary (Congenital) Immunodeficiencies
Secondary (Acquired) Immunodeficiencies
Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome
Summary
Glossary
Appendix I. Principal Features of Selected CD Molecules
Appendix II. Cytokines
Appendix III. Laboratory Techniques Commonly Used in Immunology
Index
Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai
Abul K. Abbas
Andrew H. Lichtman
Shiv Pillai
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