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Genetics: Analysis and Principles 7th Edition
Genetics: Analysis and Principles Seventh Edition:
Genetics: Analysis and Principles is a one-semester, introductory genetics textbook that takes an experimental approach to understanding genetics. By weaving one or two experiments into the narrative of each chapter, students can simultaneously explore the scientific method and understand the genetic principles that have been learned from these experiments. The pedagogy of Genetics: Analysis & Principles has been designed to foster student learning. Instead of being a collection of facts and figures,this text is intended to be an engaging and motivating textbook in which formative assessment allows students to move ahead and learn the material in a productive way.
Additional ISBNs:
∗ Print ISBN: 126057122X, 978-1260571226, 9781260571226
∗ eText ISBN: 1260473066, 9781260473063, 9781260473063
- See additional information on the Amazon.
More Details
Title Page
Copyright Page
Brief Contents
Contents
About The Author
Dedication
Preface
Connect Page
Part I Introduction
Chapter 1 Overview of Genetics
1.1 The Molecular Expression of Genes
1.2 The Relationship Between Genes and Traits
1.3 Fields of Genetics
1.4 The Science of Genetics
Part II Patterns of Inheritance
Chapter 2 Mendelian Inheritance
2.1 Mendel’s Study of Pea Plants
2.2 Law of Segregation
2.3 Law of Independent Assortment
2.4 Studying Inheritance Patterns in Humans
2.5 Probability and Statistics
Chapter 3 Chromosome Transmission During Cell Division and Sexual Reproduction
3.1 General Features of Chromosomes
3.2 Cell Division
3.3 Mitosis and Cytokinesis
3.4 Meiosis
3.5 Sexual Reproduction
3.6 The Chromosome Theory of Inheritance and Sex Chromosomes
Chapter 4 Extensions of Mendelian Inheritance
4.1 Overview of Simple Inheritance Patterns
4.2 Dominant and Recessive Alleles
4.3 Environmental Effects on Gene Expression
4.4 Incomplete Dominance, Overdominance, and Codominance
4.5 Genes on Sex Chromosomes
4.6 Sex-Influenced and Sex-Limited Inheritance
4.7 Lethal Alleles
4.8 Understanding Complex Phenotypes Caused by Mutations in Single Genes
4.9 Gene Interactions
Chapter 5 Non-Mendelian Inheritance
5.1 Maternal Effect
5.2 Epigenetics: Dosage Compensation
5.3 Epigenetics: Genomic Imprinting
5.4 Extranuclear Inheritance
Chapter 6 Genetic Linkage and Mapping in Eukaryotes
6.1 Overview of Linkage
6.2 Relationship Between Linkage and Crossing Over
6.3 Genetic Mapping in Plants and Animals
6.4 Genetic Mapping in Haploid Eukaryotes
6.5 Mitotic Recombination
Chapter 7 Genetic Transfer and Mapping in Bacteria
7.1 Overview of Genetic Transfer in Bacteria
7.2 Bacterial Conjugation
7.3 Conjugation and Mapping via Hfr Strains
7.4 Bacterial Transduction
7.5 Bacterial Transformation
7.6 Medical Relevance of Horizontal Gene Transfer
Chapter 8 Variation in Chromosome Structure and Number
8.1 Microscopic Examination of Eukaryotic Chromosomes
8.2 Changes in Chromosome Structure: An Overview
8.3 Deletions and Duplications
8.4 Inversions and Translocations
8.5 Changes in Chromosome Number: An Overview
8.6 Variation in the Number of Chromosomes Within a Set: Aneuploidy
8.7 Variation in the Number of Sets of Chromosomes
8.8 Natural and Experimental Mechanisms That Produce Variation in Chromosome Number
Part III Molecular Structure AND Replication of the Genetic Material
Chapter 9 Molecular Structure of DNA and RNA
9.1 Identification of DNA as the Genetic Material
9.2 Overview of DNA and RNA Structure
9.3 Nucleotide Structure
9.4 Structure of a DNA Strand
9.5 Discovery of the Double Helix
9.6 Structure of the DNA Double Helix
9.7 RNA Structure
Chapter 10 Molecular Structure of Chromosomes and Transposable elements
10.1 Organization of Functional Sites Along Bacterial Chromosomes
10.2 Structure of Bacterial Chromosomes
10.3 Organization of Functional Sites Along Eukaryotic Chromosomes
10.4 Sizes of Eukaryotic Genomes and Repetitive Sequences
10.5 Transposition
10.6 Structure of Eukaryotic Chromosomes in Nondividing Cells
10.7 Structure of Eukaryotic Chromosomes During Cell Division
Chapter 11 DNA Replication
11.1 Structural Overview of DNA Replication
11.2 Bacterial DNA Replication: The Formation of Two Replication Forks at the Origin of Replication
11.3 Bacterial DNA Replication: Synthesis of New DNA Strands
11.4 Bacterial DNA Replication: Chemistry and Accuracy
11.5 Eukaryotic DNA Replication
Part IV Molecular Properties of Genes
Chapter 12 Gene Transcription and RNA Modification
12.1 Overview of Transcription
12.2 Transcription in Bacteria
12.3 Transcription in Eukaryotes
12.4 RNA Modification
12.5 A Comparison of Transcription and RNA Modification in Bacteria and Eukaryotes
Chapter 13 Translation of mRNA
13.1 The Genetic Basis for Protein Synthesis
13.2 The Relationship Between the Genetic Code and Protein Synthesis
13.3 Experimental Determination of the Genetic Code
13.4 Structure and Function of tRNA
13.5 Ribosome Structure and Assembly
13.6 Stages of Translation
Chapter 14 Gene Regulation in Bacteria
14.1 Overview of Transcriptional Regulation
14.2 Regulation of the lac Operon
14.3 Regulation of the trp Operon
14.4 Translational and Posttranslational Regulation
14.5 Riboswitches
Chapter 15 Gene Regulation in Eukaryotes I: Transcriptional AND TRANSLATIONAL Regulation
15.1 Regulatory Transcription Factors
15.2 Chromatin Remodeling, Histone Variants, and Histone Modification
15.3 DNA Methylation
15.4 The ENCODE Project
15.5 Regulation of Translation
Chapter 16 Gene Regulation in Eukaryotes II: Epigenetics
16.1 Overview of Epigenetics
16.2 Heterochromatin: Function, Formation, Structure, and Maintenance
16.3 Epigenetics and Development
16.4 Paramutation
16.5 Epigenetics and Environmental Agents
Chapter 17 Non-coding RNAs
17.1 Overview of Non-coding RNAs
17.2 Non-coding RNAs: Effects on Chromatin Structure and Transcription
17.3 Non-coding RNAs: Effects on Translation, mRNA Degradation, and RNA Modifications
17.4 Non-coding RNAs and Protein Targeting
17.5 Non-coding RNAs and Genome Defense
17.6 Role of Non-coding RNAs in Human Diseases
Chapter 18 Genetics of Viruses
18.1 Virus Structure and Genetic Composition
18.2 Overview of Viral Reproductive Cycles
18.3 Bacteriophage Reproductive Cycle
18.4 HIV Reproductive Cycle
Chapter 19 Gene Mutation, DNA Repair, and Recombination
19.1 Effects of Mutations on Gene Structure and Function
19.2 Random Nature of Mutations
19.3 Spontaneous Mutations
19.4 Induced Mutations
19.5 DNA Repair
19.6 Homologous Recombination
Part V Genetic Technologies
Chapter 20 MOLECULAR Technologies
20.1 Gene Cloning Using Vectors
20.2 Polymerase Chain Reaction
20.3 DNA Sequencing
20.4 Gene Editing
20.5 Blotting Methods to Detect Gene Products
20.6 Methods for Analyzing DNA- and RNA-Binding Proteins
Chapter 21 Biotechnology
21.1 Uses of Microorganisms in Biotechnology
21.2 Genetically Modified Animals
21.3 Reproductive Cloning and Stem Cells
21.4 Genetically Modified Plants
Chapter 22 Genomics I: Analysis of DNA
22.1 Overview of Chromosome Mapping
22.2 Cytogenetic Mapping via Microscopy
22.3 Linkage Mapping via Crosses
22.4 Physical Mapping via Cloning and DNA Sequencing
22.5 Genome-Sequencing Projects
22.6 Metagenomics
Chapter 23 Genomics II: Functional Genomics, Proteomics, and Bioinformatics
23.1 Functional Genomics
23.2 Proteomics
23.3 Bioinformatics
Part VI Genetic Analysis of Individuals and Populations
Chapter 24 Medical Genetics
24.1 Inheritance Patterns of Genetic Diseases
24.2 Detection of Disease-Causing Alleles via Haplotypes
24.3 Genetic Testing and Screening
24.4 Prions
24.5 Human Gene Therapy
24.6 Personalized Medicine
Chapter 25 Genetic Basis of Cancer
25.1 Overview of Cancer
25.2 Oncogenes
25.3 Tumor-Suppressor Genes
25.4 Role of Epigenetics in Cancer
Chapter 26 Developmental genetics
26.1 Overview of Animal Development
26.2 Invertebrate Development
26.3 Vertebrate Development
26.4 Plant Development
26.5 Sex Determination in Animals
Chapter 27 Population Genetics
27.1 Genes in Populations and the Hardy-Weinberg Equation
27.2 Overview of Microevolution
27.3 Natural Selection
27.4 Genetic Drift
27.5 Migration
27.6 Nonrandom Mating
27.7 Sources of New Genetic Variation
Chapter 28 COMPLEX AND Quantitative TRAITS
28.1 Overview of Complex and Quantitative Traits
28.2 Statistical Methods for Evaluating Quantitative Traits
28.3 Polygenic Inheritance
28.4 Identification of Genes That Control Quantitative Traits
28.5 Heritability
28.6 Selective Breeding
Chapter 29 Evolutionary Genetics
29.1 Origin of Species
29.2 Phylogenetic Trees
29.3 Molecular Evolution
Glossary
Appendix A
Appendix B
Index
Robert Brooker
Rob Brooker (Ph.D., Yale University) received his B.A. in biology at Wittenberg University, Springfield, Ohio, in 1978. At Harvard, he studied lactose permease, the product of the lacY gene of the lac operon. He continues working on transporters at the University of Minnesota, where he is a Professor in the Department of Genetics, Cell Biology, and Development and has an active research laboratory. At the University of Minnesota, Dr. Brooker teaches undergraduate courses in biology, genetics, and cell biology. In addition to many other publications, he has written two undergraduate genetics texts published by McGraw-Hill: Genetics: Analysis & Principles, 4th edition, copyright 2012, and Concepts of Genetics, copyright 2012.
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