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Color Atlas of Genetics 5th Edition - 9783132414402
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Thieme Medical Publishers

Color Atlas of Genetics 5th Edition

$5.00

Format

PDF

Author(s)

Eberhard Passarge

Publisher

Thieme Medical Publishers

ISBN-10

3132414409

ISBN-13

978-3132414402

Pages

474

Language

English

Edition

5th edition | 2017

File Size

186 MB

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$63

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ISBN: 978-3132414402 SKU: MB1580 Category: Genetics Tags: Atlas, Color Atlas of Genetics, Color Atlas of Genetics 5th Edition, Genetics
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Description

Color Atlas of Genetics 5th Edition

Color Atlas of Genetics Fifth Edition:

Ever since the International Human Genome Project achieved its extraordinary goal of sequencing and mapping the entire human genome, represented by approximately 3 billion base pairs, with its far-reaching implications for understanding the causes of human genetic disorders and their diagnosis, progress in the field has not slowed down.

In the fifth edition of the bestselling Color Atlas of Genetics, readers will be rewarded with a complete and current overview of the field, with an emphasis on the interface between fundamental principles and practical applications in medicine and the role of signaling pathways in causing diseases.

Using the acclaimed Flexibook format designed for easy visual learning and retention, the atlas is invaluable for students, clinicians, and scientists interested in staying up to date in this fast-evolving area.

New fully illustrated topics in the revised fifth edition of the atlas include:

  • An overview of disorders resulting from structural changes of the genome (genomic disorders)
  • Abnormal imprinting patterns
  • Examples of impaired signal pathways (laminopathies, fibrillinopathies, cohesinopathies, and others)
  • The CRISPR-Cas system
  • Genetic features of the aging processes
  • Disorders due to rearrangements of chromatin in the cell nucleus, and others

With almost 200 stunning color plates explained by concise texts on the opposite pages, including tables presenting useful data, a glossary of terms, key references, and online resources, the atlas presents clear and accessible concepts. It is an excellent refresher for investigators in any field of medicine or biology.


Additional ISBNs:

∗ eText ISBN: 3132414417, 978-3132414419, 9783132414419

  • See additional information on the Amazon.

Table of Contents

Contents

Cover
At a Glance
Dedication
Title Page
Copyright
Preface
Acknowledgments
About the Author
Contents
Introduction
Chronology
Important Advances that Contributed to the Development of Genetics
Fundamentals
Prologue
Phylogenetic Tree of Living Organisms
Origins of Humans
Out of Africa: Toward Modern Humans
The Cell and Its Components
Genetic Background of Aging Processes
Molecular Basis of Genetics
Carbohydrates
Lipids (Fatty Acids)
Amino Acids
Nucleotides and Nucleic Acids
DNA and Its Components
DNA as a Carrier of Genetic Information
DNA Structure
DNA Replication
The Flow of Genetic Information: Transcription and Translation
Genetic Code
Eukaryotic Gene Structure
Analysis of DNA
Restriction Enzymes
DNA Amplification (PCR)
DNA Sequencing
Parallel DNA Sequencing (Next-Generation Sequencing)
DNA Cloning
DNA Libraries
Southern Blot Hybridization
Variability of DNA
DNA Variants
Genes and Mutation
Mutations Due to Base Modifications
Mutations Due to Errors in Replication
Processing of DNA
DNA Repair Systems
Transposition
Trinucleotide Repeat Expansion
Eukaryotic Cells
Cell Communication
Haploid and Diploid Yeast Cells
Cell Cycle Control
Cell Division: Mitosis
Meiosis in Germ Cells
Meiosis Prophase I
Formation of Gametes
Programmed Cell Death
Cultured Cells
Formal Genetics
The Mendelian Traits
Transmission to the Next Generation
Independent Distribution
Phenotype and Genotype: Application in Genetic Counseling
Segregation of Parental Genotypes
Monogenic Inheritance
Genetic Linkage and Recombination
Genetic Linkage and Association Analysis
Quantitative Differences in Genetic Traits
Distribution of Alleles in a Population
Hardy–Weinberg Equilibrium Principle
Geographical Differences in Allelic Distribution
Inbreeding
Twins and Twinning
Chromosomes
Chromosomes and Genes
Chromosome Organization
Functional Elements of Chromosomes
Nucleosomes
Packing DNA in Chromosomes
The Telomere
Chromosomes in Metaphase
The Banding Patterns of Human Chromosomes
Karyotype of Man and Mouse
Preparation of Metaphase Chromosomes for Analysis
Fluorescence in Situ Hybridization
Multicolor Fluorescence In Situ Hybridization (FISH) Identification of Chromosomes
Aneuploidy
Chromosome Translocation
Structural Chromosomal Aberrations
Regulation of Gene Function
Ribosomal RNA and Protein Assembly
Stages of Transcription
Basic Principles of Gene Control
Regulation of Gene Expression in Eukaryotes
DNA–Protein Interactions
Other Forms of Transcription Control
Noncoding RNAs
Targeted Gene Disruption
Epigenetic Modifications
DNA Methylation
Reversible Changes in Chromatin Structure
Genomic Imprinting
Mammalian X Chromosome Inactivation
Genetic Signal Pathways
Cellular Signal Transduction
Heterotrimeric G Proteins
TGF ? and Wnt/?-Catenin Signaling Pathways
Hedgehog and TNF Signal Pathways
The Notch/Delta Signaling Pathway
Genes in Embryonic Development
Embryonic Development Genes in Drosophila melanogaster
Hox Genes
Zebrafish: A Translucent Vertebrate
Cell Lineage in a Nematode, Caenorhabditis elegans
Genomics
Genomics
Genomics: The Study of the Organization of Genomes
Genomes of Microorganisms
Architecture of the Human Genome
Regulatory Architecture of the Human Genome
Genome Analysis with DNA Microarrays
Genome Scan and Array–Comparative Genomic Hybridization
Comparative Genomic Hybridization
Genome-Wide Association Study
The Dynamic Genome: Mobile Genetic Elements
Genome Editing by the CRISPR-Cas System
Evolution of Genes and Genomes
Comparative Genomics
Genomic Structure of the Human X and Y Chromosomes
The Mitochondrial Genome of Man
Genetics in Medicine
Genetic Classification of Diseases
Genomic Disorders
Disorders due to Dysregulated Chromatin Structure
Disorders Resulting from Rearrangement of Cis-Regulatory Elements
Disorders Resulting from Defects in Telomeres
Disorders Resulting from Defective Lamins
Disorders Resulting from Dysfunctional Cohesin
Disorders due to Dysfunctional Cilia (Ciliopathies)
Neurocristopathies
Dysregulated RAS-MAPK Signaling Pathway
Unstable Repeat Expansion
Fragile X Syndrome
Imprinting Disorders
Imbalanced Homeostasis
Mitochondrial Diseases
Chloride Channel Defects: Cystic Fibrosis
Genetic Defects in Ion Channels: LQT Syndromes
?1-Antitrypsin Deficiency
Hemophilia A and B
von Willebrand Bleeding Disease
Pharmacogenetics
Cytochrome P450 (CYP) Genes
Metabolic Disorders
Genetics of Diabetes Mellitus
Amino Acid Degradation and Urea Cycle Disorders
Cholesterol Biosynthesis Pathway
Distal Cholesterol Biosynthesis Pathway
Familial Hypercholesterolemia
LDL Receptor Mutations
Lysosomal Storage Disorders
Lysosomal Enzyme Defects
Mucopolysaccharide Storage Diseases
Peroxisomal Disorders
Immune System
Components of the Immune System
Immunoglobulin Molecules
Generation of Antibody Diversity
Immunoglobulin Gene Rearrangement
T-cell Receptor
The MHC Region
Evolution of the Immunoglobulin Superfamily
Primary Immunodeficiency Diseases
Origins of Cancer
Genetic Causes of Cancer
Categories of Cancer Genes
Cancer Genomes
The TP53 Tumor Suppressor Gene
The APC Gene and Polyposis Coli
Breast and Ovarian Cancer Susceptibility Genes
Oncogenic Chromosome Translocations
Retinoblastoma
Neurofibromatosis
Genomic Instability Diseases
DNA Excision Repair Disorders
Impaired Cell and Tissue Structure
Cytoskeletal Proteins in Erythrocytes
Hereditary Muscular Dystrophies
Duchenne’s Muscular Dystrophy
FGF Receptor Mutations in Skeletal Dysplasias
Marfan’s and Loeys–Dietz Syndromes
Collagen Molecule Disorders
Osteogenesis Imperfecta
Molecular Basis of Bone Development
Hemoglobin Disorders
Hemoglobin
Hemoglobin Genes
Sickle Cell Disease
Mutations in Globin Genes
The Thalassemias
Hereditary Persistence of Fetal Hemoglobin (HPFH)
Sex Determination and Differentiation
Mammalian Sex Determination
Sex Differentiation
Disorders of Sexual Development
Congenital Adrenal Hyperplasia
Sensory Perception
Rhodopsin, a Photoreceptor
Pigmentary Retinal Degeneration
Color Vision
Auditory System
Odorant Receptors
Mammalian Taste Receptors
Chromosomal Aberrations
Numerical Chromosomal Aberrations
Triploidy, Monosomy X, Additional X or Y Chromosome
Microdeletion Syndromes
A Brief Guide to Genetic Diagnosis
A Brief Guide to Genetic Diagnosis
Gene and Stem Cell Therapy
Morbid Anatomy of the Human Genome
Chromosomal Locations of Human Genetic Diseases
Chromosomal Locations—Alphabetical List
Appendix
Glossary
Index

About the Author

Eberhard Passarge

Eberhard Passarge

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