How the Immune System Works 6th Edition

How the Immune System Works 6th Edition:

Cover
Acknowledgments
How to Use This Book
About the Companion Website
Lecture 1 An Overview
Introduction
Physical Barriers
The Innate Immune System
The Adaptive Immune System
A Comparison of the Innate and Adaptive Immune Systems
The Innate System Rules!
Epilogue
Lecture 2 The Innate Immune System
Introduction
The Complement System
The Professional Phagocytes
How Immune System Sentinels Recognize Invaders
How the Innate Immune System Deals with Viruses
The Innate Immune System a Cooperative Effort
A Proportional Response
Summary Figure
Lecture 3 B Cells and Antibodies
Introduction
The B Cell Receptor
How the BCR Signals
How B Cells are Activated
Class Switching
Antibody Classes and their Functions
Somatic Hypermutation
B Cells Make a Career Choice
Summary Figure
Lecture 4 The Magic of Antigen Presentation
Introduction
Class I MHC Molecules
Class II MHC Molecules
Antigen Presentation by Class I MHC Molecules
Antigen Presentation by Class II MHC Molecules
Antigen Presenting Cells
The Logic of Class I MHC Presentation
The Logic of Class II MHC Presentation
Cross-Presentation
Non-Classical MHC Molecules and Lipid Presentation
MHC Proteins and Organ Transplants
Summary Figure
Lecture 5 T Cell Activation
Introduction
T Cell Receptors
How a T Cell’s Receptors Signal
CD4 and CD8 Co-Receptors
Co-Stimulation
A Time-Lapse Photo of Helper T Cell Activation
How Killer T Cells are Activated
Fail-Safe Activation
Lecture 6 T Cells at Work
Introduction
Helper T Cells as Cytokine Factories
The Dendritic Cell as “Coach” of the Immune System Team
Th1 Helper T Cells
Th2 Helper T Cells
Th17 Helper T Cells
Th0 Helper T Cells
Locking in the Helper T Cell Profile
Delayed-Type Hypersensitivity
How CTLs Kill
Summary Figure
Lecture 7 Secondary Lymphoid Organs and Lymphocyte Trafficking
Introduction
Lymphoid Follicles
High Endothelial Venules
Lymph Nodes
Peyer’s Patches
The Spleen
The Logic of Secondary Lymphoid Organs
Lymphocyte Trafficking
Why Mothers Kiss Their Babies
Lecture 8 Restraining the Immune System
Introduction
Attenuating the Immune Response
Deactivating the System
Life is Short
Exhaustion
Lecture 9 Self Tolerance and MHC Restriction
Introduction
The Thymus
MHC Restriction
The Logic of MHC Restriction
Thymic Testing for Tolerance of Self
Graduation
The Riddle of MHC Restriction and Tolerance Induction
Tolerance by Ignorance
Tolerance Induction in Secondary Lymphoid Organs
Peripheral Tolerance Induction
Tolerance Due to Activation-Induced Cell Death
B Cell Tolerance
Maintenance of B Cell Tolerance in Germinal Centers
Positive Selection of Natural Killer Cells
Lecture 10 Immunological Memory
Introduction
Innate Memory
Adaptive Memory
Properties of Adaptive Memory Cells
Comparing B and T Cell Memories
Innate Versus Adaptive Memory
Lecture 11 The Intestinal Immune System
Introduction
Intestinal Architecture
Challenges Faced by the Intestinal Immune System
Responding Gently to Limited Threats
The Intestinal Immune System’s Response to Pathogens
How to Respond?
Lecture 12 The Immune System Gone Wrong
Introduction
Diseases Caused by Defects in Immune Regulation
Autoimmune Disease
Lecture 13 Immunodeficiency
Introduction
Genetic Defects Leading to Immunodeficiency
AIDS
Lecture 14 Vaccines
Introduction
Generating Memory Helper T and B Cells
Generating Memory Killer T Cells
Strategies for Vaccine Development
Will there be an Aids Vaccine?
Vaccination to Prevent Virus-Associated Cancer
Vaccine Adjuvants
Lecture 15 Cancer and the Immune System
Introduction
Cancer is a Control System Problem
Classification of Cancer Cells
Immune Surveillance Against Cancer
Immune Surveillance by Macrophages and NK Cells
Lecture 16 Immunotherapy
Introduction
Immunotherapy Using Monoclonal Antibodies
Immunotherapy Using T Cells
Glossary
List of Acronyms and Abbreviations
Index
End User License Agreement

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