Clinical Biochemistry 10th Edition

Cover
Title Page
Preface
List of abbreviations
About the companion website
1 Requesting and interpreting tests
Introduction
Collection of specimens
The use of clinical biochemistry tests
Point of care testing (POCT)
Interpretation of clinical biochemistry tests
Sources of variation in test results
Clinical audit in laboratory medicine
FURTHER READING
2 Disturbances of water, sodium and potassium balance
Introduction
Water and sodium balance
Potassium balance
Fluid and electrolyte balance in surgical patients
Intravenous fluid administration
FURTHER READING
3 Acid–base balance and oxygen transport
Introduction
Transport of carbon dioxide
Renal mechanisms for reabsorption and H excretion
Buffering of hydrogen ions
Investigating acid–base balance
Disturbances ofacid–base status
Interpretation of results of acid–base assessment
Other investigations in acid–base assessment
Treatment of acid–base disturbances
Oxygen transport
Indications for full blood acid–base and oxygen measurements
Respiratory insufficiency
Oxygen therapy
FURTHER READING
4 Renal disease
Introduction
Impaired renal function
Tests of glomerular function
Tests of tubular function
Renal handling of sodium and potassium
Acute kidney injury
Chronic kidney disease
Proteinuria
Renal stones
FURTHER READING
5 Disorders of calcium, phosphate and magnesium metabolism
Calcium homeostasis
Hypercalcaemia
Hypocalcaemia
Metabolic bone disease
Phosphate metabolism
Magnesium metabolism
6 Diabetes mellitus and hypoglycaemia
Glucose homeostasis
Diabetes mellitus
Hypoglycaemia
FURTHER READING
7 Disorders of the hypothalamus and pituitary
Introduction
The hypothalamus
Anterior pituitary hormones
Endocrine changes in anorexia nervosa
Anterior pituitary disease and its investigation
Posterior pituitary hormones
8 Abnormalities of thyroid function
Introduction
Thyroid hormone synthesis, action and metabolism
Investigations to determine thyroid status
Interpreting results of thyroid function tests
Thyroid cancer
Miscellaneous tests and thyroid disease
9 Disorders of the adrenal cortex and medulla
Introduction
Regulation of adrenal steroid hormone synthesis and secretion
Investigation of suspected adrenocortical hyperfunction
Investigation of suspected adrenocortical insufficiency
Biochemical tests in the investigation of hypertension
Phaeochromocytoma
10 Investigation of gonadal function infertility, menstrual irregularities and hirsutism
Introduction
Male gonadal function
Investigation of infertility and male hypogonadism
Female gonadal function
11 Pregnancy and antenatal screening
Introduction
The foetoplacental unit
Effect of pregnancy on biochemical tests
Complications in pregnancy
Pre‐natal diagnosis of foetal abnormalities
FURTHER READING
12 Cardiovascular disorders
The diagnosis of myocardial infarction
The diagnosis of heart failure
The diagnosis of thromboembolic disease
Cardiovascular risk factors
Metabolism of plasma lipoproteins
Investigation of plasma lipid abnormalities
Other biochemical cardiovascular risk factors or markers
Calculation of cardiovascular risk and its treatment by lipid lowering
FURTHER READING
13 Liver disease
Introduction
Structure of the liver
Liver function tests
The place of biochemical tests in the diagnosis of liver disease
14 Gastrointestinal tract disease
Introduction
Stomach
The pancreas
Small intestine and colon
The investigation of malabsorption and diarrhoea
FURTHER READING
15 Nutrition
Introduction
Principal dietary constituents
Assessment of nutritional status
Nutritional support
Major nutritional problems
FURTHER READING
16 Inflammation, immunity and paraproteinaemia
Introduction
Changes in plasma proteins in trauma, infection and inflammation – ‘the acute‐phase response’
The immunoglobulins and disease
17 Malignancy and tumour markers
Introduction
Tumour markers commonly used in clinical practice
18 Disorders of iron and porphyrin metabolism
Introduction
Iron metabolism
Porphyrin metabolism
Abnormal derivatives of haemoglobin
19 Uric acid, gout and purine metabolism
Introduction
Purine metabolism and uric acid
Serum urate
Hyperuricaemia
Hypouricaemia
FURTHER READING
20 Central nervous system and cerebrospinal fluid
Introduction
CSF composition
Examination of CSF
FURTHER READING
21 Therapeutic drug monitoring and chemical toxicology
Introduction
Therapeutic drug monitoring (TDM)
Acute poisoning
Industrial and occupational hazards
FURTHER READING
22 Clinical biochemistry in paediatrics and the elderly
Introduction
Paediatrics
Inherited metabolic disorders
The elderly
Index
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