Concepts of Genetics 3rd Edition

Cover
Title
Copyright
About the Authors
Brief Contents
Table of Contents
Preface
Acknowledgments
A Visual Guide to Concepts of Genetics
Part I Introduction
Chapter 1 Overview of Genetics
1.1 The Molecular Expression of Genes
1.2 The Relationship Between Genes and Traits
1.3 Fields of Genetics
1.4 The Science of Genetics
Part II Patterns of Inheritance
Chapter 2 Reproduction and Chromosome Transmission
2.1 General Features of Chromosomes
2.2 Cell Division
2.3 Mitosis and Cytokinesis
2.4 Meiosis
2.5 Sexual Reproduction
Chapter 3 Mendelian Inheritance
3.1 Mendel’s Study of Pea Plants
3.2 Law of Segregation
3.3 Law of Independent Assortment
3.4 Chromosome Theory of Inheritance
3.5 Studying Inheritance Patterns in Humans
3.6 Probability and Statistics
Chapter 4 Sex Determination and Sex Chromosomes
4.1 Mechanisms of Sex Determination Among Various Species
4.2 Dosage Compensation and X-Chromosome Inactivation in Mammals
4.3 Properties of the X and Y Chromosomes in Mammals
4.4 Transmission Patterns for X-Linked Genes
Chapter 5 Extensions of Mendelian Inheritance
5.1 Overview of Simple Inheritance Patterns
5.2 Dominant and Recessive Alleles
5.3 Environmental Effects On Gene Expression
5.4 Incomplete Dominance, Overdominance, and Codominance
5.5 Sex-Influenced and Sex-Limited Inheritance
5.6 Lethal Alleles
5.7 Understanding Complex Phenotypes Caused By Mutations in Single Genes
5.8 Gene Interaction
Chapter 6 Extranuclear Inheritance, Imprinting, and Maternal Effect
6.1 Extranuclear Inheritance: Chloroplasts
6.2 Extranuclear Inheritance: Mitochondria
6.3 Theory of Endosymbiosis
6.4 Epigenetics: Imprinting
6.5 Maternal Effect
Chapter 7 Genetic Linkage and Mapping in Eukaryotes
7.1 Overview of Linkage
7.2 Relationship Between Linkage and Crossing Over
7.3 Genetic Mapping in Plants and Animals
7.4 Mitotic Recombination
Chapter 8 Variation in Chromosome Structure and Number
8.1 Microscopic Examination of Eukaryotic Chromosomes
8.2 Changes in Chromosome Structure: An Overview
8.3 Deletions and Duplications
8.4 Inversions and Translocations
8.5 Changes in Chromosome Number: An Overview
8.6 Variation in the Number of Chromosomes Within A Set: Aneuploidy
8.7 Variation in the Number of Sets of Chromosomes
8.8 Mechanisms That Produce Variation in Chromosome Number
Chapter 9 Genetics of Bacteria
9.1 Overview of Genetic Transfer in Bacteria
9.2 Bacterial Conjugation
9.3 Conjugation and Mapping via Hfr Strains
9.4 Bacterial Transduction
9.5 Bacterial Transformation
9.6 Medical Relevance of Horizontal Gene Transfer
10 Genetics of Viruses
10.1 Virus Structure and Genetic Composition
10.2 Viral Reproductive Cycles
Part III Molecular Structure and Replication of the Genetic Material
Chapter 11 Molecular Structure of DNA and RNA
11.1 Identification of DNA as the Genetic Material
11.2 Overview of DNA and RNA Structure
11.3 Nucleotide Structure
11.4 Structure of a DNA Strand
11.5 Discovery of the Double Helix
11.6 Structure of the DNA Double Helix
11.7 RNA Structure
Chapter 12 Molecular Structure of Chromosomes and Transposition
12.1 Organization of Functional Sites Along Bacterial Chromosomes
12.2 Structure of Bacterial Chromosomes
12.3 Organization of Functional Sites Along Eukaryotic Chromosomes
12.4 Sizes of Eukaryotic Genomes and Repetitive Sequences
12.5 Transposition
12.6 Structure of Eukaryotic Chromosomes in Nondividing Cells
12.7 Structure of Eukaryotic Chromosomes During Cell Division
Chapter 13 DNA Replication and Recombination
13.1 Structural Overview of DNA Replication
13.2 Bacterial DNA Replication: The Formation of Two Replication Forks at the Origin of Replication
13.3 Bacterial DNA Replication: Synthesis of New DNA Strands
13.4 Bacterial DNA Replication: Chemistry and Accuracy
13.5 Eukaryotic DNA Replication
13.6 Homologous Recombination
Part IV Molecular Properties of Genes
Chapter 14 Gene Transcription and RNA Modification
14.1 Overview of Transcription
14.2 Transcription in Bacteria
14.3 Transcription in Eukaryotes
14.4 RNA Modification
14.5 A Comparison of Transcription and RNA Modification in Bacteria and Eukaryotes
Chapter 15 Translation of mRNA
15.1 The Genetic Basis for Protein Synthesis
15.2 The Relationship Between the Genetic Code and Protein Synthesis
15.3 Experimental Determination of the Genetic Code
15.4 Structure and Function of tRNA
15.5 Ribosome Structure and Assembly
15.6 Stages of Translation
Chapter 16 Gene Regulation in Bacteria
16.1 Overview of Transcriptional Regulation
16.2 Regulation of the lac Operon
16.3 Regulation of the trp Operon
16.4 Translational and Posttranslational Regulation
16.5 Riboswitches
Chapter 17 Gene Regulation in Eukaryotes
17.1 Regulatory Transcription Factors
17.2 Chromatin Remodeling, Histone Variants, and Histone Modification
17.3 DNA Methylation
17.4 Overview of Epigenetics
17.5 Epigenetics and Development
17.6 Epigenetics and Environmental Agents
17.7 Regulation of Translation and RNA Stability
Chapter 18 Non-Coding RNAs
18.1 Overview of Non-Coding RNAs
18.2 Non-Coding RNAs: Effects on Chromatin Structure and Transcription
18.3 Non-Coding RNAs: Effects on Translation and mRNA Degradation
18.4 Non-Coding RNAs and Protein Targeting
18.5 Non-Coding RNAs and Genome Defense
18.6 Role of Non-Coding RNAs in Human Diseases
Chapter 19 Gene Mutation and DNA Repair
19.1 Effects of Mutations on Gene Structure and Function
19.2 Random Nature of Mutations
19.3 Spontaneous Mutations
19.4 Induced Mutations
19.5 DNA Repair
Part V Genetic Technologies
Chapter 20 Molecular Technologies
20.1 Gene Cloning Using Vectors
20.2 Polymerase Chain Reaction
20.3 Reproductive Cloning and Stem Cells
20.4 DNA Sequencing
20.5 Gene Editing
20.6 Blotting Methods To Detect Gene Products
20.7 Analyzing DNA- and RNA-Binding Proteins
Chapter 21 Genomics
21.1 Overview of Chromosome Mapping
21.2 In situ Hybridization
21.3 Molecular Markers
21.4 Genome-Sequencing Projects
21.5 Metagenomics
21.6 Functional Genomics
Part VI Genetic Analysis of Individuals and Populations
Chapter 22 Medical Genetics and Cancer
22.1 Inheritance Patterns of Genetic Diseases
22.2 Detection of Disease-Causing Alleles via Haplotypes
22.3 Genetic Testing and Screening
22.4 Overview of Cancer
22.5 Oncogenes
22.6 Tumor-Suppressor Genes
22.7 Role of Epigenetics in Cancer
22.8 Personalized Medicine
Chapter 23 Population Genetics
23.1 Genes in Populations and the Hardy-Weinberg Equation
23.2 Overview of Microevolution
23.3 Natural Selection
23.4 Genetic Drift
23.5 Migration
23.6 Nonrandom Mating
23.7 Sources of New Genetic Variation
Chapter 24 Quantitative Genetics
24.1 Overview of Quantitative Traits
24.2 Statistical Methods for Evaluating Quantitative Traits
24.3 Polygenic Inheritance
24.4 Identification of Genes That Control Quantitative Traits
24.5 Heritability
24.6 Selective Breeding
Appendix A
Appendix B
Glossary
Index

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